Carmela R. Abraham, PhD

Professor of Biochemistry and Pharmacology & Experimental Therapeutics

Klotho: The Key to Longevity

Carmela R. Abraham, PhD, devoted her entire career to the study of aging and Alzheimer’s disease (AD). She obtained her B.Sc. in Biology at Tel Aviv University and a PhD in Neuroscience at Harvard University. She is Professor of Biochemistry and Pharmacology & Experimental Therapeutics at Boston University School of Medicine. Dr. Abraham’s research is both basic and translational. The basic research focuses on understanding the pathologic mechanisms leading to AD and to other neurodegenerative diseases. Dr. Abraham studies ways to protect the nerve cells that die in these diseases and, thus, prevent brain dysfunction. Her group discovered that, in vitro, Klotho, whose expression decreases with age, is neuroprotective, anti-oxidative and anti-inflammatory. In vivo, overexpression of Klotho improved the outcomes in mouse models of AD, MS and ALS. Since higher Klotho levels are associated with better outcomes, Dr. Abraham is exploring various modalities to elevate Klotho expression in the brain.


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